Management of Overanticoagulation with UFH or LMWH
Reversal of unfractionated heparin​
| Time since administration (min) | Protamine dose per 100 IU heparin |
|---|---|
| 30 | 1.0 - 1.5 mg |
| 30 - 60 | 0.5 - 0.7 mg |
| >= 120 | 0.25 - 0.375 mg |
note
Max 50 mg in any one dose
Max administration rate 5 mg/min
Protamine acts almost immediately and persists for approximately 2 hours
APTT may be checked within 5 - 15 minutes of the protamine dose